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Research
Transplantation
Kidney-resident macrophages
The defined role of macrophages in kidney transplantation remains enigmatic. Different macrophage subsets play important but opposing roles in graft rejection and acceptance, suggesting their functional heterogeneity in solid organ transplantation. Given that tissue-resident cells of donor origin might temporarily persist in the transplant and shape the alloimmune response, we study in this DFG funded research the exact roles of kidney-resident (krMΦ) and monocyte-derived macrophages (mdMΦs) for allograft outcome.
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